Deciphering brain ageing and neurodegeneration.
The brain is a multiscale system. To understand it, we need a new approach that brings together research still pursued in isolation, across scales, methods, and disciplines.
With partners at Imperial College London and OTH Regensburg, we are advancing that work on the drivers of brain ageing and neurodegeneration—and the considerable heterogeneity in individual disease trajectories.
Understanding why individuals differ in vulnerability, progression, and treatment response requires connecting molecular, imaging, clinical, environmental, and behavioral information across biological scales and time. Our speech biomarker technologies contribute repeatable measures of cognitive and behavioral function to this broader effort, linking everyday functional performance with patient-specific models of underlying disease processes.
Precision digital twins provide a framework for integrating these complementary observations into models that evolve as new information becomes available. Our research explores how this integration can support mechanistic understanding, individual trajectory modelling, and the investigation of intervention responses.
Our PIM-BrainTwin perspective develops one example: a physics-informed, multiscale framework for estimating underlying disease states and remaining compensatory capacity. Alzheimer’s disease serves as the initial use case within an open, modular research framework designed to accommodate other neurological conditions and alternative mechanistic hypotheses.